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Regis Philbin and Kelly Ripa Guest Star as Themselves In the Season Premiere of "Ugly Betty"

Emmy-winning daytime television mavens Regis Philbin and Kelly Ripa will guest star as themselves on ABC's "Ugly Betty" in the show's season premiere, airing September 25. In the episode, magazine editors Wilhelmina Slater (Vanessa Williams) and Alexis Meade (Rebecca Romijn) appear on "Live with Regis and Kelly" to promote the new issue of Mode magazine. With Wilhelmina at the helm for the first time since taking over from Alexis' brother, Daniel, the two hosts can't help but put Alexis on the hot seat.

"Ugly Betty" stars America Ferrera as Betty Suarez, Eric Mabius as Daniel Meade, Vanessa Williams as Wilhelmina Slater, Ana Ortiz as Hilda, Tony Plana as Ignacio, Ashley Jensen as Christina, Becki Newton as Amanda, Mark Indelicato as Justin, Michael Urie as Marc and Judith Light as Claire Meade. Rebecca Romijn as Alexis and Freddy Rodriguez as Gio are recurring guest stars.

Executive producers are Silvio Horta ("Urban Legend"), Academy Award-nominee and Emmy Award winner Salma Hayek, Jose Tamez, Joel Fields ("Dirt," "Commander in Chief") and Richard Heus. Co-executive producers are Sheila Lawrence, Victor Nelli Jr., Henry Alonso Myers, Bill Wrubel and Chris Black.

"Ugly Betty," a production of ABC Studios, airs Thursdays from 8:00-9:00 p.m. ET, on the ABC Television Network.