PA: Due to some graphic content, viewer discretion is advised.

WHEN HOUSE AND HIS TEAM RACE AGAINST THE CLOCK TO DIAGNOSE THE SOURCE OF A MAN'S ILLNESS, THE CLUES POINT TO A SHOCKING SUSPECT ON "HOUSE" TUESDAY, MARCH 28, ON FOX

Samantha Mathis Guest-Stars

House and his team take on a new patient, Bob, who comes to Princeton Plainsboro Teaching Hospital after suffering from a breathing attack while role-playing in the bedroom with his wife (guest star Samantha Mathis). All the symptoms point to heavy metal poisoning, but the tests do not. Meanwhile, as the team goes through its diagnostic process, House is wreaking havoc in the clinic, telling a patient that he got a sexually transmitted disease from his wife. When the wife confronts House about it, he tricks the patient and his wife into divulging the truth. In addition, Wilson has moved in with House and things are not going too smoothly. After House and his team treat Bob for a number of things, including food allergies and lupus, with no results, House is still sure it's heavy metal poisoning. When all the usual metals turn up negative, House confronts Bob's wife as to the origin of Bob's deadly illness, and all signs point to the wife in the "Clueless" episode of HOUSE airing Tuesday, March 28 (9:00-10:00 PM ET/PT). (HOU-215) (TV-14 D, L)

Cast: Hugh Laurie as Dr. Gregory House; Lisa Edelstein as Dr. Lisa Cuddy; Omar Epps as Dr. Eric Foreman; Robert Sean Leonard as Dr. James Wilson; Jennifer Morrison as Dr. Allison Cameron; Jesse Spencer as Dr. Robert Chase.

Guest Cast: Samantha Mathis as Maria; Eddie Mills as Bob; Peter Birkenhead as Vincent; Stephanie Erb as Charlotte; Yareli Arizmendi as Lady.