WHILE SAMANTHA CONTINUES HER AFFAIR WITH TODD, SHE BEGINS TO THINK THAT REGINA IS HAVING AN AFFAIR OF HER OWN, ON ABC'S "SAMANTHA WHO?"

"The Affair" � While Samantha continues her affair with Todd � who's still seeing a clueless Chloe -- she becomes convinced that Regina is having a rendezvous of her own. Meanwhile, Andrea toys with the idea of opening up a coffee shop with Dena, on "Samantha Who?," MONDAY, MAY 5 (9:32-10:02 p.m., ET) on the ABC Television Network.

"Samantha Who?" stars Christina Applegate as Samantha, Jennifer Esposito as Andrea, Kevin Dunn as Howard, Melissa McCarthy as Dena, Tim Russ as Frank with Barry Watson as Todd and Jean Smart as Regina.

Guest starring are Tony Winters as man and Soledad Campos as woman.

"The Affair" was written by Bob Kushell and directed by Paul Lazarus.

"Samantha Who?" is broadcast in 720 Progressive (720P), ABC's selected HDTV format, with 5.1-channel surround sound and Spanish subtitles via secondary closed captioning. A TV parental guideline will be posted closer to airdate.

This episode of "Samantha Who?" will be available on ABC.com the day after airing on the network for users to watch online.